Mod Organizer 2 has a work around called ' Configure profiles'.

There may be a number of plugins needed for mod functionality of the Nemesis body and therefore it is highly recommended to use Mod Organizer 2, rather than Vortex. Warning! Nemesis body suit is not official in Fallout 4: New Vegas. Nemesis Suit Atomic Beauty (CBP-OCBP-OCBPC).Until the remake of the highly anticipated New Vegas, the unofficial theme of our modded New Vegas adventure is witnessing the remnants of Legion spawning around the Fallout New England (F4) area trying to reorganize. Caesar's Legion spawned from the Grand Canyon area ( Van Buren) migrating west to Nevada. In 2281, Legate Lanius commented that the West would fall as the East fell and that all the land between would bear the mark of Legion. The main story of Fallout: New Vegas takes place in the year 2281. A very limited selection of these mods are available on Xbox and PS4. This page suggests up to 100 mods that you can install to enrich your New Vegas universe. PC users, it is strongly recommended to use Mod Organizer 2 so that you can configure a profile dedicated to New Vegas, without interrupting your currently installed mods! Do NOT use the inferior Vortex which limits you at the 254 plugin cap with no work around.

Fallout 4 new creatures mod